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\u4e16\u754c\u4e0a\u6240\u6709\u7684\u751f\u7269\u90fd\u9069\u5408\u5403\u5929\u7136\u98df\u7269\uff0c\u53ea\u6709\u7d93\u6fdf\u52d5\u7269\u624d\u6703\u88ab\u9935\u98df\u4eba\u5de5\u5408\u6210\u7684\u98fc\u6599\uff0c\u53bb\u7cbe\u7b97\u63db\u8089\u6bd4\u597d\u5728\u5bb0\u6bba\u524d\u8ce3\u5f97\u597d\u50f9\u9322\u3002\u6108\u65e9\u958b\u59cb\u5403\u5929\u7136\u98df\u7269\uff0c\u6bdb\u5b69\u6108\u5065\u5eb7\u3002\u4e5f\u6709\u4e00\u4e9b\u7814\u7a76\u8b49\u660e\uff0c\u6108\u65e9\u5403\u65b0\u9bae\u7684\u98df\u7269\uff0c\u6108\u6c92\u6709\u76ae\u819a\u6216\u6d88\u5316\u554f\u984c\u3002\u518d\u4e5f\u4e0d\u7528\u56e0\u70ba\u4e00\u9ede\u5c0f\u6bdb\u75c5\uff0c\u7378\u91ab\u8001\u6cbb\u4e0d\u597d\uff0c\u6216\u6108\u6cbb\u6108\u9677\u5165\u60e1\u6027\u5faa\u74b0\uff0c\u904e\u5ea6\u91ab\u7642\u7684\u5922\u9b58\u3002\u8d8a\u4f86\u8d8a\u591a\u7684\u5bb6\u9577\u4e0d\u9858\u610f\u5728\u4e0d\u5c0b\u627e\u554f\u984c\u6839\u6e90\u7684\u60c5\u6cc1\u4e0b\uff0c\u6cbb\u6a19\u4e0d\u6cbb\u672c\uff0c\u56e0\u70ba\u5e38\u8b58\u544a\u8a34\u4ed6\u5011\uff0c\u5065\u5eb7\u7684\u57fa\u790e\u5c31\u662f\u71df\u990a\u3002<\/p>\n\n\n\n

\u72ac\u8c93\u9700\u8981\u9ad8\u8cea\u91cf\u7684\u52d5\u7269\u86cb\u767d\u8cea\u3001\u8102\u80aa\u548c\u5c11\u91cf\u852c\u679c\u7e96\u7dad\u3001\u5fae\u91cf\u7926\u7269\u8cea\u3001\u7dad\u751f\u7d20\u548c\u5929\u7136\u7684\u8102\u80aa\u9178\u3002\u72ac\u8c93\u9700\u8981\u7d14\u6de8\u3001\u65b0\u9bae\u3001\u6c34\u5206\u5bc6\u96c6\u7684\u65b0\u9bae\u5929\u7136\u98df\u7269\uff0c\u4e0d\u9700\u8981\u7a40\u7269\u3001\u586b\u5145\u5291\u3001\u4eba\u5de5\u9632\u8150\u5291\u3001\u8272\u7d20\u3001\u6dfb\u52a0\u5291\u3001\u526f\u7522\u54c1\u6216\u9ad8\u5ea6\u52a0\u5de5\u5f8c\u7522\u751f\u7684\u665a\u671f\u7cd6\u57fa\u5316\u7d42\u7522\u7269<\/strong> (AGEs)<\/strong>\u3002\u6bdb\u5b69\u8ddf\u6211\u5011\u4e00\u6a23\uff0c\u53ef\u4ee5\u5403\u4e00\u4e9b\u52a0\u5de5\u98df\u54c1\uff0c\u4f46\u4e00\u8f29\u5b50\u5403\u5783\u573e\u98df\u54c1\u6703\u5c0e\u81f4\u5931\u53bb\u5065\u5eb7\u3002\u72ac\u8c93\u53ef\u80fd\u6bd4\u6211\u5011\u5403\u7684\u5178\u578b\u897f\u65b9\u52a0\u5de5\u98f2\u98df\u651d\u5165\u66f4\u591a\u7684AGEs\u3002\u6211\u5011\u7684\u6bdb\u5b69\u4e00\u751f\u90fd\u5728\u5403\u540c\u6a23\u7684\u98df\u7269\uff0c\u5982\u679c\u4ed6\u5011\u5728\u98f2\u98df\u4e2d\u63a5\u89f8\u5230AGEs\uff0c\u4e5f\u53ef\u80fd\u6703\u5c0e\u81f4\u51fa\u73fe\u67d0\u4e9b\u75be\u75c5\u3002\u98fc\u6599\u4e7e\u7ce7\u53ca\u7f50\u982d\u5e7e\u4e4e\u5168\u90e8\u63a1\u7528\u9ad8\u6eab\u9ad8\u58d3\u7684\u88fd\u9020\u6280\u8853\uff0c\u9ad8\u6eab\u9ad8\u58d3\u7684\u88fd\u9020\u904e\u7a0b\u6703\u7522\u751f\u6885\u7d0d\u53cd\u61c9(Maillard Reaction)\u6885\u7d0d\u53cd\u61c9\u6703\u7522\u751fAGEs\u7684\u7269\u8cea\u3002\u72ac\u8c93\u7f50\u982d\u88e1\u7684AGEs\u7684\u7269\u8cea\u5927\u65bc\u98fc\u6599\u4e7e\u7ce7\uff0c\u9577\u671f\u5403\u98fc\u6599\u4e7e\u7ce7\u7684\u72ac\u8c93\uff0c\u9ad4\u5167\u7684AGEs\u542b\u91cf\u662f\u4eba\u985e\u768438\uff5e122\u500d\uff0c\u5403\u7f50\u982d\u7684\u72ac\u8c93\u7684\u9ad4\u5167\u542b\u91cf\u500d\u6578\u6703\u518d\u66f4\u9ad8\u3002
AGEs\u5728\u8178\u9053\u4e2d\u88ab\u5438\u6536\u4e26\u9032\u5165\u5faa\u74b0\u7136\u5f8c\u5206\u4f48\u5230\u8eab\u9ad4\u7684\u5404\u500b\u90e8\u4f4d\u3002\u7531\u65bcAGEs\u53c8\u5927\u53c8\u7b28\u91cd\uff0c\u5b83\u5011\u4e0d\u6613\u964d\u89e3\uff0c\u56e0\u6b64\u6703\u4e0d\u65b7\u7a4d\u7d2f\u4e26\u9010\u6f38\u6210\u70ba\u5168\u8eab\u86cb\u767d\u8cea\u7d50\u69cb\u7684\u4e00\u90e8\u5206\u3002\u7814\u7a76\u958b\u59cb\u8b49\u660e\u9019\u4e9b AGE \u4fee\u98fe\u7684\u86cb\u767d\u8cea\u5c0d\u4eba\u985e\u548c\u6211\u5011\u7684\u72ac\u8c93\u540c\u4f34\u7684\u5065\u5eb7\u548c\u75be\u75c5\u6709\u591a\u7a2e\u5f71\u97ff\u3002
\u4ee5\u4e0b\u662fAGEs \u7684\u4e00\u4e9b\u5df2\u77e5\u5f71\u97ff\uff1a- AGEs \u6703\u964d\u4f4e\u98df\u7269\u4e2d\u67d0\u4e9b\u6c28\u57fa\u9178\u7684\u53ef\u5229\u7528\u6027- AGEs \u6703\u523a\u6fc0\u708e\u75c7\u53cd\u61c9\uff0c\u9020\u6210\u6162\u6027\u5168\u8eab\u708e\u75c7\u72c0\u614b\uff0c\u9019\u8207\u4eba\u985e\u548c\u72d7\u7684\u764c\u75c7\u767c\u5c55\u6709\u95dc\u3002- AGEs \u6703\u963b\u7919\u7d44\u7e54\u7684\u4fee\u5fa9\uff0c\u5c24\u5176\u662f\u86cb\u767d\u8cea\u542b\u91cf\u9ad8\u7684\u7d44\u7e54\uff0c\u5982\u97cc\u5e36\u548c\u808c\u8171\u3002\u4e5f\u5c31\u662f\u8aaa\u9019\u6703\u5c0e\u81f4\u66f4\u5feb\u901f\u7684\u8870\u8001\u8de1\u8c61\u3002- \u4eba\u985e\u4e2d\u7684 AGEs \u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u3001\u814e\u81df\u75be\u75c5\u3001\u8996\u7db2\u819c\u75c5\u8b8a\u3001\u9aa8\u95dc\u7bc0\u708e\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5\u548c\u7cd6\u5c3f\u75c5\u6709\u95dc\u3002- \u5728\u7cd6\u5c3f\u75c5\u3001\u767d\u5167\u969c\u3001\u9aa8\u95dc\u7bc0\u708e\u3001\u72ac\u8a8d\u77e5\u529f\u80fd\u969c\u7919\u7d9c\u5408\u75c7\u3001\u8840\u7ba1\u529f\u80fd\u969c\u7919\u548c\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u7684\u75be\u75c5\u7576\u4e2d\u90fd\u53ef\u4ee5\u767c\u73fe\u60a3\u72ac\u7684\u9ad4\u5167AGEs\u6c34\u5e73\u5347\u9ad8\u3002- \u514d\u75ab\u7cfb\u7d71\u8207 AGEs \u76f8\u4e92\u4f5c\u7528\uff0c\u5c0e\u81f4\u708e\u75c7\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f\u589e\u52a0\u3002\u9019\u6703\u5c0e\u81f4\u8178\u9053\u904e\u654f\u53cd\u61c9\u589e\u52a0\uff0c\u8868\u73fe\u70ba\u708e\u75c7\u6027\u8178\u75c5 \u3002\u5982\u679c\u4f60\u8a66\u5716\u63a1\u7528\u5404\u7a2e\u91ab\u7642\u3001\u4fdd\u5065\u624b\u6bb5\u6216\u662f\u8cfc\u8cb7\u5404\u7a2e\u9ad8\u50f9\u7684\u4fdd\u5065\u98df\u54c1\uff0c\u5e0c\u671b\u53ef\u4ee5\u5ef6\u7de9\u4f60\u5bb6\u72ac\u8c93\u7684\u8001\u5316\u6216\u662f\u6162\u6027\u75be\u75c5\u7684\u60e1\u5316\uff0c\u537b\u9084\u5728\u6301\u7e8c\u6bcf\u5929\u9935\u98df\u72ac\u8c93\u90a3\u4e9b\u5145\u6effAGEs\u7269\u8cea\u7684\u98fc\u6599\u4e7e\u7ce7\u3001\u7f50\u982d\uff0c\u4e0d\u5c31\u90fd\u662f\u5728\u7de3\u6728\u6c42\u9b5a\u55ce\uff1f<\/p>\n\n\n\n

\u6709\u4e9b\u5bb6\u9577\u56e0\u70ba\u5de5\u4f5c\u5fd9\u788c\uff0c\u53ef\u80fd\u7121\u6cd5\u9935\u98df\u5b8c\u5168\u65b0\u9bae\u7684\u98df\u7269\uff0c\u4f46\u53ef\u4ee5\u52aa\u529b\u5f9e\u6bcf\u9031\u9935\u98df\u4e00\u5169\u9910\u7684\u65b0\u9bae\u98df\u7269\u958b\u59cb\uff0c\u6216\u5229\u7528\u9592\u6687\u6642\u9593\u89aa\u81ea\u4e0b\u5eda\u70ba\u6bdb\u5b69\u6599\u7406\u65b0\u9bae\u98df\u7269\u3002\u4f60\u8d8a\u7528\u5fc3\u5728\u7528\u771f\u6b63\u7684\u5929\u7136\u98df\u7269\u4ee3\u66ff\u9ad8\u5ea6\u52a0\u5de5\u7684\u98fc\u6599\u7f50\u982d\uff0c\u4f60\u7684\u6bdb\u5b69\u5b50\u5c31\u6703\u8d8a\u5065\u5eb7\u3002<\/p>\n\n\n\n

\u6bdb\u5b69\u6700\u4f73\u71df\u990a\u7684\u9996\u9078\u662f\u591a\u5143\u98f2\u98df\u591a\u6a23\u8f2a\u66ff\uff0c\u65b0\u9bae\u7684\u81ea\u88fd\u98f2\u98df\uff0c\u751f\u5403\u6216\u5fae\u52a0\u71b1\u71d9\u719f\u5373\u53ef\u3002\u5982\u679c\u4f60\u60f3\u81ea\u716e\u9bae\u98df\uff0f\u751f\u98df\uff0c\u90a3\u9ebc\u4f60\u5fc5\u9808\u6709\u57fa\u672c\u7684\u72ac\u8c93\u71df\u990a\u9700\u6c42\u77e5\u8b58\uff0c\u4ee5\u53ca\u5404\u7a2e\u71df\u990a\u914d\u6bd4\u7684\u539f\u5247\uff0c\u9084\u5fc5\u9808\u6dfb\u52a0\u5929\u7136\u7684\u9223\u8cea\u9aa8\u7c89\u3002\u574a\u9593\u6709\u5404\u7a2e\u95dc\u65bc\u4ec0\u9ebc\u53ef\u4ee5\u5403\uff0c\u4ec0\u9ebc\u4e0d\u80fd\u5403\u7684\u98df\u7269\uff0c\u6709\u4e9b\u662f\u8ff7\u601d\u8ddf\u8b20\u8a00\uff0c\u53ef\u4ee5\u5728\u6211\u5011\u6240\u7d93\u71df\u7684\u793e\u5718<\/a>\uff08FB\u641c\u5c0b\u6bdb\u5b69\u5065\u5eb7\u9bae\u98df\u540c\u597d\u6703<\/a>\uff09\u4e2d\u641c\u5c0b\u6700\u6b63\u78ba\u7684\u9bae\u98df\u77e5\u8b58\u53ca\u8cc7\u8a0a\u3002<\/p>\n\n\n\n

\u9084\u662f\u8001\u8a71\u4e00\u53e5\uff0c\u4e0d\u504f\u98df\uff0c\u4e0d\u6311\u98df\uff0c\u5403\u7576\u5b63\u7684\uff0c\u65b0\u9bae\u7684\uff0c\u638c\u63e1\u6b63\u78ba\u6bd4\u4f8b\uff0c\u907f\u958b\u7d55\u5c0d\u4e0d\u80fd\u98df\u7528\u7684\u98df\u6750\uff0c\u90a3\u9ebc\u4f60\u5e7e\u4e4e\u4e0d\u7528\u64d4\u5fc3\u6bdb\u5b69\u6703\u6709\u5403\u932f\u98df\u7269\u7684\u98a8\u96aa\u3002<\/p>\n\n\n\n

\u5982\u679c\u4f60\u7121\u6cd5\u70ba\u6bdb\u5b69\u81ea\u88fd\u98df\u7269\uff0c\u9078\u64c7\u6b77\u53f2\u60a0\u4e45\u3001\u6709\u4fe1\u8b7d\u7684\u5546\u696d\u9bae\u98df\uff0f\u751f\u98df\u63d0\u4f9b\u8005\uff0c\u8b93\u81ea\u5df1\u5076\u723e\u5598\u53e3\u6c23\uff0c\u7bc0\u7701\u4e0b\u4f86\u7684\u6642\u9593\u597d\u597d\u4eab\u53d7\u6bdb\u5b69\u966a\u4f34\u7684\u6642\u9593\uff0c\u4e5f\u662f\u53e6\u4e00\u7a2e\u9078\u64c7\u3002<\/p>\n\n\n\n

\u53c3\u8003\u8cc7\u6599\uff1a1.John WG, Lamb BJ. The maillard or browning reaction in diabetes. Eye 1993;7:230-7.https:\/\/www.semanticscholar.org\/……\/03379e2887ab1dc……<\/a>
2.Quantitation of Maillard Reaction Products in Commercially Available Pet FoodsCharlotte van Rooijen,\u2020 Guido Bosch,*,\u2020 Antonius F. B. van der Poel,\u2020 Peter A. Wierenga,\u2021 Lucille Alexander,\u00a7 and Wouter H. Hendriks\u2020,#https:\/\/pubmed.ncbi.nlm.nih.gov\/25088431\/<\/a>
3.Ramasay R, Vannucci J, Yan D, Herold K, Yan F, Schmidt AM. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 2005;15:16-28R. doi: 10.1093\/glycob\/cwi053.https:\/\/academic.oup.com\/glycob\/article\/15\/7\/16R\/689769<\/a>
4.Vet World 2013\u7378\u91ab\u671f\u520a\u4f86\u6e90Gentzel JB. Does contemporary canine diet cause cancer? A review. Vet World 2013;6:532-9. Doi: 10.14202\/vetworld\/2013.632-639https:\/\/www.semanticscholar.org\/……\/a6ce4f9a13d2f7c……<\/a>
5.Vlassara H, Bucala R, Striker LJ. Pathogenic effects of advanced glycosylation: biochemical, biologic and clinical implications for diabetes and aging. Lab Invest 1994;70:138-51.https:\/\/pubmed.ncbi.nlm.nih.gov\/8139257\/<\/a>
6.Teodorowicz M, Hendriks WH, Wichers HJ, Savelkoul HFJ. Immunomodulation by processed animal feed: The role of Maillard reaction products and advanced glycation end-products (AGEs). Frontiers in Immunology 2018;9:2088 doi: 10.3389\/fimmu.2018.02088.https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6146089\/<\/a><\/p>\n\n\n\n

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